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    Connectome

    Page 43
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      and connectomes, [>]

      as connectopathies, [>], [>]

      and defects in proteins, [>]

      depression, [>], [>]

      drugs for, [>]–[>] (see also Drugs)

      antidepressants, [>], [>]–[>], [>]–[>]

      development of, [>]–[>], [>]

      for neurodegenerative disorders, [>], [>], [>]

      infectious, [>]–[>], [>]

      investment in therapies for, [>]

      lissencephaly, [>]–[>]

      methods of search for, [>]–[>]

      microcephaly, [>]

      nature vs. nurture in, [>]–[>]

      obsessive-compulsive disorder, [>], [>]

      schizophrenia, [>], [>]–[>], [>], [>] (see also Schizophrenia)

      studies of with animals, [>]–[>]

      studies of from balanced populations, [>]

      syphilis, [>]–[>], [>]

      Tourette’s syndome, [>]

      treatment of

      and connectopathies, [>]

      drugs in, [>]–[>]

      for neurodevelopmental disorders, [>]–[>]

      optimism about, [>]–[>]

      question of abuse of, [>]

      timing in, [>]

      training regimens in, [>]

      See also Brain disorders; Neurodegenerative disorders; Neurodevelopmental disorders

      Merge error, [>]

      Merkle, Ralph, [>]

      Method of loci, [>]

      Methuselah Foundation, [>]

      MGN (medial geniculate nucleus), [>]

      Microbiology, Leeuwenhoek as father of, [>]

      Microcephaly, congenital, [>], [>]

      Microscopic organisms, and microscope, [>]

      Microscopy, [>], [>]

      for connectome exploration, [>]

      of dead brains, [>]

      differential interference contrast (DIC), [>]

      electron, [>]–[>], [>] (see also Electron microscope)

      serial electron, [>]–[>], [>]–[>], [>], [>], [>]

      and Leeuwenhoek, [>]

      light, [>], [>]

      serial, [>]

      transmission electron, [>]

      Microtomes, [>]

      Mind reading, [>]

      Minds

      and connectomes, [>]

      difference in due to connectomes, [>]

      See also Self

      “Mind uploading.” See Computer simulation; “Uploading”

      Minos (king of Crete) and Minotaur, [>], [>]

      Minsky, Marvin, [>]

      Miracles, [>]–[>]

      modern, [>]

      Miswiring, [>], [>]

      Mitchell, Silas Weir, [>]

      Modha, Dharmendra, [>]–[>], [>], [>]

      Molaison, Henry Gustav, [>]

      Monkey cortex

      connections between visual areas of, [>], [>]

      map of, [>], [>]

      Moore, Gordon, [>]

      Moore’s Law, [>], [>], [>]

      Morality, and naturalistic fallacy, [>]

      Morse code as analogy to action potentials, [>]–[>]

      Motor homunculus, [>], [>], [>]

      Motor neurons, [>]

      Mozart, Wolfgang Amadeus, starling as pet of, [>]

      MRC Laboratory for Molecular Biology, Cambridge, England, [>]

      MRI. See Magnetic resonance imaging

      MTL (medial temporal lobe), [>]–[>]

      and memory, [>]–[>]

      Multiple intelligences, [>]

      Multiple sclerosis, [>]

      Muscle fibers, contraction of, [>]

      Muscles, and synaptic inhibition, [>]

      Myelin and myelination, [>]–[>], [>], [>]

      “Myeloarchitecture,” [>]

      Myrdal, Gunnar, [>]

      Myth of Sisyphus, The (Camus), [>]

      “Nanobots,” [>]

      National Institutes of Health (NIH), and Human Connectome Project, [>]

      Nature-nurture relation, [>]–[>]

      in autism and schizophrenia, [>]

      and connectomes, [>]

      and twin studies, [>]–[>]

      Negative feedback, [>]

      Neocognitron, [>]–[>]

      Neocortex, [>], [>], [>]

      double bouquet cell of, [>], [>]

      region comparable to in birds, [>]

      Neocortical plasticity, [>]–[>]

      Neo-phrenologists and neo-phrenology

      and brain size, [>]–[>], [>]

      on memories and learning, [>]–[>], [>], [>], [>], [>]

      and mental retardation, [>]

      Nerves (poultry), axons as, [>]–[>]

      Nervous system, [>]

      Neural code, [>]–[>]

      Neural Darwinism, [>]–[>], [>], [>], [>], [>], [>]

      for adult neurons, [>], [>]

      Neurites, [>]–[>], [>]–[>], [>], [>]

      axons, [>]–[>] (see also Axons)

      dendrites, [>]–[>] (see also Dendrites)

      and synapses, [>]

      three-dimensional rendering of fragments of, [>]

      Neuroanatomy, [>]

      limitations of, [>]–[>]

      Neuroblasts, [>]

      Neurodegenerative disorders

      Alzheimer’s disease, [>], [>], [>], [>], [>]

      drugs for, [>], [>], [>]

      mouse models of, [>]

      Parkinson’s disease, [>]–[>], [>], [>], [>], [>]

      See also Mental disorders and disabilities

      Neurodevelopmental disorders

      autism and schizophrenia as, [>]–[>] (see also Autism; Schizophrenia)

      treatment for

      prevention, [>]–[>]

      through rewiring, [>]

      See also Mental disorders and disabilities

      Neurologists, [>]

      Neuromodulators, [>]–[>]

      Neuronal connectome, [>], [>], [>], [>], [>], [>], [>], [>]

      Neurons, [>], [>]–[>]

      activity of, [>]–[>]

      collective action of, [>]–[>]

      communication between, [>]–[>]

      excitatory and inhibitory synapses and neurons in, [>]–[>]

      and nonspiking neurons, [>]–[>]

      through pathways, [>]–[>]

      and “weighted voting model,” [>]–[>], [>]

      as computing, [>]–[>]

      and connectionism, [>], [>]–[>]

      connections among, [>], [>]

      part-whole rule in, [>]–[>]

      rules of, [>]–[>]

      and connections to outside world, [>]

      creation of, [>], [>]

      in parallel with elimination, [>]–[>]

      question of in adults, [>]

      and Dale’s Principle, [>]

      degeneration and death of, [>], [>]

      elimination of, [>]–[>], [>]–[>]

      excitatory, [>]–[>]

      extrasynaptic interactions of, [>]–[>], [>]

      four R’s in change of, [>], [>]–[>], [>] (see also Reconnection; Regeneration; Reweighting of synapse; Rewiring of brain)

      and genes, [>], [>]

      Golgi staining of, [>]

      image of, [>]

      inhibitory, [>]–[>], [>], [>]

      organization of (dumb into smart), [>]

      in perception, [>]

      previous impossibility of seeing, [>]

      reading of thoughts and perceptions from, [>]

      of retina (reconstructed automatically by computer), [>]

      rules of connection governing, [>]–[>]

      simulations of, [>]

      spiking for specific celebrity, [>]

      and synapses, [>] (see also Synapse)

      technological progress in imaging of, [>]–[>]

      tracing branches of through cross-sections, [>]

      types of, [>], [>]–[>], [>]–[>], [>]–[>], [>]

      and C. elegans, [>]–[>]

      and connectionism, [>]–[>]

      models of, [>]

      pyramidal, [>], [>]–[>], [>]–[>], [>]

      variety of, [>]

      “weighted voting model” of, [>]–[>], [>], [>], [>], [>], [>]

      Neuropathology(ies)
    , [>]

      and autism or schizophrenia treatment, [>]

      for diverse genetic defects, [>]

      and drug evaluation, [>]

      Neuroscience and neuroscientists, [>]

      of change, [>]

      and challenge of empirical investigation of connectome, [>]–[>]

      and challenge of overwhelming amounts of information, [>], [>]

      and changing our brains, [>]

      and dilemma of phrenology vs. connectionism, [>]

      and extrasynaptic interactions of neurons, [>]–[>]

      and fashioning of connectome, [>]–[>]

      and four R’s, [>] (see also Reconnection; Regeneration; Reweighting of synapse; Rewiring of brain)

      of future (connectomics), [>]

      vs. “ghost in the machine,” [>]

      “grand challenges” for, [>]

      and great inventions, [>]–[>]

      and hypotheses about memory, [>]–[>]

      and mind vs. brain, [>]

      and self-improvement, [>]

      through simulation, [>]

      stains important in, [>]

      unachieved benefits of, [>]

      understanding brain as goal of, [>]

      and unknown, [>]–[>]

      Neurotransmitter, [>], [>]–[>], [>]–[>], [>], [>], [>]–[>]

      Dale’s Principle on, [>]

      discovery of, [>]–[>]

      surplus or deficiency of in mental disorders, [>]

      New Organon (Bacon), [>]

      Newton, Sir Isaac, [>], [>]

      Nicolelis, Miguel, [>]

      Nicotine, [>]

      and brain function, [>]

      Nissl, Franz, [>]

      Nobel Prize in economics, [>]

      Nondeclarative (implicit) memory, [>]–[>]

      Notebook parable about memory theories, [>]–[>]

      Nottebohm, Fernando, [>]–[>], [>], [>]

      Nucleotides, [>], [>], [>]

      Obsessive-compulsive disorder, [>], [>]

      Occipital lobe, [>]–[>], [>], [>], [>]

      Olfactory bulb, [>], [>]

      Olson, Charles, [>], [>]

      On Memory (Aristotle), [>]–[>]

      Optic nerve, [>]

      Optogenetics, [>]

      Organization of Behavior, The (Hebb), [>]

      “Organology,” [>]

      Organ transplantation, [>]–[>]

      of brain, [>]–[>]

      Pangloss, Dr. (Voltaire character), [>]

      Paparazzi metaphor for perception, [>]–[>]

      Paré, Ambroise, [>]–[>]

      Parietal lobe, [>]–[>], [>]

      learning to juggle as thickening, [>]

      left parietal lobe, [>]

      Parietal lobule, inferior, [>]

      Parkinson’s disease (PD), [>]–[>], [>], [>], [>]

      stem-cell treatment for, [>]

      Pascal, Blaise, [>]

      on immensity of universe, [>]–[>], [>], [>]

      Pascal’s Wager, [>]–[>], [>], [>]

      Pasteur, Louis, [>], [>]

      Patch clamp recording, [>]

      Pathways, [>]–[>]

      and neural voting, [>]–[>]

      and nonspiking neurons, [>]–[>]

      Pearson, Karl, [>]

      Pearson’s correlation coefficient, [>]

      Penfield, Wilder, [>], [>]–[>]

      Penicillin, discovery of, [>]

      Pensées (Pascal), [>], [>]

      Perception

      association in, [>] (see also Association)

      through collection of specific functions, [>]–[>]

      hierarchical organization of, [>]–[>], [>]–[>]

      and neural code, [>]–[>]

      “grandmother cell” theory of, [>]

      machines incapable of (Leibniz), [>]

      memory compared with, [>]

      and MTL, [>]

      neuron functions in, [>]

      Plato on (wax metaphor), [>]

      spiking provides picture of, [>]

      Perceptron, [>], [>], [>], [>]

      Peripheral nervous system (PNS), [>]

      Peters’ Rule, [>]

      Phantom limb, [>], [>]–[>]

      and rewiring, [>]

      Phaedrus (Plato), [>]

      Pharmaceutical industry

      and drug development, [>]

      as Ehrlich’s invention, [>]

      Phencyclidine (PCP), [>]

      Phenothiazines, [>], [>]

      Pheromone, [>]

      Philosophical Transactions of the Royal Society of London, [>]

      Photoreceptors, [>], [>]–[>]

      Phrenological map, [>]

      Phrenology and phrenologists, [>], [>], [>], [>]

      and factory analogy, [>]

      need to imrove on, [>]

      and study of cortical plasticity, [>]

      Piltdown Man, [>]

      Plasticity, [>], [>]

      cortical, [>]

      “cross-modal,” [>]

      rule of, [>]–[>]

      vs. stability, [>]

      Plastination, [>], [>]–[>]

      Plato

      carving metaphor of, [>], [>]

      on memory, [>], [>]

      Plum, Fred, [>]

      Pompeii, discovery of, [>]–[>]

      Ponce de León, Juan, [>]

      Pony Express, [>]–[>]

      Pope, Alexander, [>]

      Porter, Keith, [>]

      Posterior hippocampus, [>]

      Postsynaptic density, [>]

      Primary visual cortex (V1), [>], [>], [>]

      Probability

      and Pascal’s Wager, [>]–[>]

      and rational decision-making, [>]

      and reanimation issues, [>]–[>]

      “Problem of Serial Order in Behavior, The” (Lashley), [>]

      Profound Hypothermia and Circulatory Arrest (PHCA) (procedure), [>]

      Prospect of Immortality, The (Ettinger), [>]

      Proteins, [>], [>]–[>], [>]

      and genes, [>], [>]

      ion channels, [>]

      and Parkinson’s disease, [>]

     


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